This book gathers the proceedings of the Dahlem Conference "Optogenetics. Challenges and Perspectives" (September 2-5, 2012). It is edited by Peter Hegemann and Stephan Sigrist.
- A concise overview of the methodology, basic research and new clinical applications for optogenetics
- Content developed with top international scientists and students in a "Dahlem Conference" workshop
- Color illustrations for better visualization of complex structures
Optogenetics: Tools for Controlling and Monitoring Neuronal Activity, Progress in Brain Research Vol. 196Progress in Brain Research gathers 12 chapters of about 20 pages each. The volume is edited by Thomas Knöpfel and Edward S. Boyden and chooses to embed monitoring and controlling strategies into a unique, comprehensive concept of optogenetics, as explicited in the introductory chapter [PDF].
Table of Contents:
- Chapter 1: A comprehensive concept of optogenetics [PDF].
- Chapter 2: Optogenetic excitation of neurons with channelrhodopsins: Light instrumentation, expression systems, and channelrhodopsin variants.
- Chapter 3: Genetically encoded molecular tools for light-driven silencing of targeted neurons.
- Chapter 4: Genetically encoded probes for optical imaging of brain electrical activity.
- Chapter 5: Neural activity imaging with genetically encoded calcium indicators.
- Chapter 6: Manipulating cellular processes using optical control of protein–protein interactions.
- Chapter 7: Two-photon optogenetics.
- Chapter 8: Zebrafish as an appealing model for optogenetic studies.
- Chapter 9: Genetic targeting of specific neuronal cell types in the cerebral cortex.
- Chapter 10: Mouse transgenic approaches in optogenetics.
- Chapter 11: Optogenetics in the nonhuman primate.
- Chapter 12: Optogenetic reporters: Fluorescent protein-based genetically encoded indicators of signaling and metabolism in the brain.
Imaging in Neuroscience: A Laboratory Manual, by F. Helmchen and A. Konnerth
- F. Helmchen, A. Konnerth. Imaging in Neuroscience: A Laboratory Manual. Cold Spring Harbor Laboratory Press]. 736 pages, due May 2011, $240.
Neuroscientists have often pioneered the use of new visualization techniques. Imaging in Neuroscience: A Laboratory Manual provides the definitive collection of methods in use in this groundbreaking field. With more than 90 chapters, the manual offers a depth of coverage unavailable from any other source. Sections focus on imaging at the molecular level, axons and nerve terminals, spines and dendrites, neurons and circuits in vitro, neurons and circuits in vivo, glia, brain dynamics and behavior, and brain pathology. Protocols range from basic techniques to recent breakthroughs. Imaging in Neuroscience: A Laboratory Manual is an essential guide to discovering and implementing these techniques.
Guide to Research Techniques in Neuroscience, by Matt Carter and Jennifer Shieh
Neuroscience is by definition a multidisciplinary field: some scientists study genes and proteins at the molecular level while others study neural circuitry. A single topic such as the auditory system can be studied using techniques from genetics, imaging, biochemistry, or electrophysiology. A young scientist must learn how to read the primary literature and then develop their own experiments. This book offers that scientist an overview of mainstream research techniques, provides guidelines on how to choose one technique over another, offers tips on analyzing data, and provides a list of references for additional detailed study. This book can also assist an experienced scientist understand published studies conducted outside their own subfield. *Written by Stanford University graduate students in neuroscience to provide a "hands-on" approach for other neuroscience graduate students Techniques within one field will be compared so that user can select best technique for their experimentChapters include references (key articles, books, protocols) for additional detailed studyData Analysis boxes in each chapter help with data interpretation and offer guidelines on how best to represent results"Walk-through" boxes guide students through the experiment step-by-step
Genetic Dissection of Neural Circuits and Behavior, Volume 65, edited by Stephen F. Goodwin
Genes interact with environment, experience, and the biology of the brain to shape an animal's behavior. This latest volume in Advances in Genetics, organized according to the most widely used model organisms:
- describes the latest genetic discoveries in relation to neural circuit development and activity.
- Explores latest topics in neural circuits and behavior research in zebrafish, drosophila, c.elegans, and mouse models.
- Includes methods for testing with ethical, legal, and social implications* Critically analyzes prospects future prospects.